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Antimycobacterial, antioxidant and cytotoxic activities of essential oil of gall of Pistacia atlantica Desf. From Algeria

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dc.contributor.author Sifi, I
dc.contributor.author Dzoyem, Jean Paul
dc.contributor.author Ouinten, M
dc.contributor.author Yousfi, M
dc.contributor.author McGaw, Lyndy Joy
dc.contributor.author Eloff, Jacobus Nicolaas
dc.date.accessioned 2019-06-10T12:56:48Z
dc.date.available 2019-06-10T12:56:48Z
dc.date.issued 2015
dc.identifier.uri http://e-biblio.univ-mosta.dz/handle/123456789/10769
dc.description.abstract Background: The aim of this study was to assess the antimycobacterial, antioxidant and the cytotoxic activities of the essential oil from the gall part of Pistacia atlantica Desf from Algeria. Materials and Methods: The antimycobacterial activity was evaluated by the broth microdilution method against three species of mycobacteria: Mycobacterium smegmatis, Mycobacterium aurum and Mycobacterium fortuitum. Antioxidant activity was determined using free-radical scavenging assays. The safety of essential oil was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on C3A and Vero monkey kidney cells. Results: The minimal inhibitory concentration (MIC) values ranged from 0.16 to 2.5 mg/mL with minimal bactericidal concentration (MBC) values ranged from 0.62 to >2.5 mg/mL. The antioxidant activity showed IC50 values ranged between 417.61 - >2000μg/mL and 495.6 - >2000μg/mL for DPPH and ABTS assay respectively. The cytotoxicity assay showed LC50 ranged between 26.47 to 93.64 μg/mL against Vero cells and 74.29 to 225.40 μg/mL against C3A. The results of this study show that the essential oils from the gall of P. atlantica have low toxicity and moderate activity against fast growing M. smegmatis and M. aurum. Conclusion: These results substantiate their potential as used in the treatment of non-tuberculous mycobacterial infections. This finding is predictive of their activity against M. tuberculosis, therefore, further study might be considered to investigate the activity against pathogenic Mycobacterium strains. en_US
dc.publisher African Journal of Traditional, Complementary and Alternative Medicines en_US
dc.subject Pistacia atlantica en_US
dc.subject Essential oil en_US
dc.subject Antimycobacterial en_US
dc.subject Antioxidant en_US
dc.subject Cytotoxicity en_US
dc.title Antimycobacterial, antioxidant and cytotoxic activities of essential oil of gall of Pistacia atlantica Desf. From Algeria en_US
dc.type Article en_US


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