Résumé:
Chemicals with neurotoxic effects are found to be very different, citing the
Aluminum. The versatility of Aluminum chemistry will ensure its burgeoning use in the
future in all manner of applications. This very same chemistry will also ensure its increased
biological availability in all biota including Man. We do not know enough about the
biological chemistry of a chronic and sub-acute exposure to Aluminum to be able to predict
its impact on human health.
Although the hypothesis of a link between Aluminum and Alzheimer's disease (AD)
has been supported by several epidemiological studies, there is much controversy
regarding these findings and their interpretation.
Nowadays, the toxicity of Aluminum is well established in the animal’s laboratory, and the
neurotoxic effect is studies by means of behavioral tests, memory tests and histological and
biological analysis.
There is no doubt that the drugs discovered for neurodegenerative disease are far from
ideal, there are no more than acetyl cholinesterase inhibitors, in fact alternative
medicine could be moderate and protect nerves from neurotoxicity and AD.
Several means were considered to fight against this severe health problems, including herbal
medicine which is based on the effectiveness of the antioxidant on lesions induced by metals.
Curcumin is one of strong medicinal species used to reduce the damage caused by
aluminum, it is a powerful antioxydant that prove an oxidative stress effect against
reactions cascade of neurofibrillary tangles.
Our aims is to clarify the role of Curcumin with a fixative of absorption as a protective
and therapeutic agent against neurodegenerative disorders and Alzheimer's disease induced
by Aluminum (AlCl3) on the pyramidal cells in cerebral cortex and hippocampus of albino
mice, by means of Two experiences realized with a different exposition of albino mice;
sub-acute and chronic exposure with a different manner (Oral and IP) on Curcumin with
a fixative of absorption and AlCl3.
