Abstract:
Parkinson disease is a common neurodegenerative disease. Deficiency of
dopamine is thought to be responsible for development of Parkinson Disease.
Exercise training has been associated with improvements in patients with
Parkinson Disease. The objective of the present study is to explore the effect of
exercise training on the expression of HSP70 and iNOS in brains of mice with
induced Parkinson Disease.
Forty albino mice were selected and assigned into four groups: Sedentary
control (SC, N=10), exercised control (EC, N=10), Parkinson Disease (PD,
N=10) and exercised Parkinson Disease (EPD, N=10). MPTP protocol was used
to induce Parkinson Disease by injections of 10 doses of MPTP (25 mg/kg) and
probenecid (250 mg/kg) over 5 weeks. After the protocols treadmill exercise
training had been finished, samples from the brain tissues were assessed by
immunohistochemistry to examine the expression of HSP70 in the four groups of
animals.
The results of the present study showed that the expression of HSP70 was
reduced in the brain of mice with Parkinson Disease significantly (P < 0.05)
compared with control groups. The results also showed that exercise training
increased the expression of HSP70 in EC significantly (P < 0.05) compared with
control group, and insignificantly (P>0.05) in EPD compared with PD.
Although the increased expression of HSP70 in exercised Parkinson
Disease was not significant, it has a potential role in improved the status of mice
with Parkinson Disease and it may have a potential therapeutic role.
The data of the present study also showed significant expression of iNOS
in brainsof rats with induced Parkinson Disease compared with control group (P
0.000) compared with control group, and this expression was significantly
decreased in exercised group (P 0.000).
