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Physicochemical Properties and Liposomal Formulations of Hydrolysate Fractions of Four Sea Cucumbers (Holothuroidea: Echinodermata) from the Northwestern Algerian Coast

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dc.contributor.author MECHETA, Asmaa
dc.contributor.author HANACHI, Amine
dc.contributor.author JEANDEL, Carole
dc.contributor.author ARAB-TAHRANY, Elmira
dc.contributor.author BIANCHI, Arnaud
dc.contributor.author VELOT, Emilie
dc.contributor.author MEZALI, Karim
dc.contributor.author LINDER, Michel
dc.date.accessioned 2020-07-04T23:24:07Z
dc.date.available 2020-07-04T23:24:07Z
dc.date.issued 2020-06-28
dc.identifier.issn 1420-3049
dc.identifier.uri http://e-biblio.univ-mosta.dz/handle/123456789/15460
dc.description.abstract To promote the nutritional and pharmacological values of four sea cucumber species (Holothuria poli, H. tubulosa, H. arguinensis, and H. sanctori), harvested from the Algerian coast, we aimed to study their proximate composition, fatty acid profile and angiotensin-converting enzyme (ACE) inhibitory activity. Their phospholipids were also used to elaborate nanoliposomes and to encapsulate peptides obtained from the same source. After the physico-chemical characterization of nanoliposomes and peptides, in vitro analyses were realized. The four holothurian species showed a high amount of protein (49.26–69.34%), and an impressive lipid profile of 27 fatty acids, mainly composed of polar fatty acids (91.16–93.85%), with a high polyunsaturated fatty acids (PUFA) content (50.90–71.80%), particularly eicosapentaenoic acid (EPA) (5.07–8.76%) and docosahexaenoic acid (DHA) (4.86–7.25%). A high phospholipids amount was also found (55.20–69.85%), mainly composed of phosphatidylcholine (PC) (51.48–58.56%). Their peptide fractions exhibited a high ACE inhibitory activity (IC50 0.30 to 0.51 mg/mL). The results also showed that the nanoliposomes do not induce cytotoxicity and cell death in human MSCs and no perturbation of proliferation for all the times and the tested concentrations, as well as the combined nanoliposomes and hydrolysates (HTS) at a concentration of 0.1 mg/mL. All four sea cucumbers show potential as a new source for omega-3, omega-6, and bioactive peptides. en_US
dc.language.iso en en_US
dc.publisher Molecules en_US
dc.subject sea cucumbers; PUFA; peptide; ACE; nanoliposome; phospholipids; Algerian coast en_US
dc.title Physicochemical Properties and Liposomal Formulations of Hydrolysate Fractions of Four Sea Cucumbers (Holothuroidea: Echinodermata) from the Northwestern Algerian Coast en_US
dc.type Article en_US


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