Les probiotiques et les maladies Inflammatoires Intestinales

Abstract

These study aims to determinethe benefit use of probiotics as a preventive or curative measure in chronic inflammatory bowel diseases (IBD) such as Crohn's disease, or ulcerative colitis. Three articles scientists whose research themes treat the subject through in vitro, in vivo and clinical trials. The first article of Shri Pathmakanthan and his collaborators. (2004); demonstrates the beneficial immunomodulatory effect of Lactobacillus plantarum 299 in cells extracted from inflamed human colon by determining the pattern of cytokine secretion (interleukin [IL] -1b, tumor necrosis factor [TNF] -a, interferon [IFN] -g and IL-10) and their cellular sources in mononuclear cells isolated from colonic mucosa of normal and ulcerative colitis (UC) in response to probiotic and pathogenic bacteria. The second selected article of Schlutz and his collaborators. (2002), determines the Lactobacillus plantarum 299Vuse in the treatment and prevention of spontaneous colitis in interleukin-10 deficient mice, according to four different protocols varying the times of oral administration of the probiotic bacteria compared to colonization by SPF bacteria in IL-10 - / - mice and evaluated the effect of this probiotic organism on immune activation of mucous membranes. The last article of Ajit Sood his co-authors. (2009); is about a multicenter, randomized, double-blind, placebo-controlled trial of a high potency probiotic, VSL # 3, for the treatment of mild to moderately active UC in affected patients. The authors results approved that Lactobacillus plantarum has beneficial immunomodulatory activity by increasing the synthesis and secretion of IL-10 in macrophages and cells derived from the inflamed colon. This may provide a mechanism by which probiotic bacteria enhance inappropriate inflammation and induce tolerance. Also, L. plantarum may attenuate immune-mediated colitis and suggest a therapeutic role in chronic inflammatory bowel disease and that the VSL # 3 probiotic complex is safe and effective in achieving clinical responses and remissions in patients with Mild to moderately active UC.