Carence en vitamine D chez les sujets atteints d’hépatopathies dans la région de Mostaganem et d’Oran.

Abstract

Vitamin D is becoming recognized as an important physiological regulator outside of its classical role in skeletal homeostasis. There is growing evidence linking vitamin D to liver disease and the consequences of its deficiency on it. The goal of this modest work is to conduct an observational study in these patients to assess vitamin D levels and its impact on the parameters of their liver function. In order to highlight the relevance of this aspect, this study focused on a total of seventy patients from the region of Mostaganem and Oran followed for a chronic hepatic abnormality with different etiologies, it is a heterogeneous population with 58% (n= 41) women and 42% (n= 29) men with a mean age of (46 ± 17.41 years) of which 42% of the entire population has hepatic cirrhosis, 52% have viral hepatitis and 6% have a liver with steatosis. The determination of vitamin D status in this study was performed using a direct immunological technique that allows the quantitative determination of 25(OH)D in serum. The average minimum level of 25(OH)D among subjects is (9.38±0.12 ng/ml), and the maximum is (20.6±1.77 ng/ml). There was a significant difference in vitamin D levels in patients with more severe disease (cirrhosis) compared to other types of diseases. The study of the relationship between vitamin D status and the different liver balance parameters revealed a found inverse correlation between the level of 25(OH)D and that of TGP, GGT, PAL, total bilirubin and the marker of inflammation; CRP. While no significant correlation was found with TGO level. Based on the data found in this study, widespread vitamin D deficiency was found in patients with liver disease. Acting upon on the affected population means giving ourselves the opportunity to limit the occurrence and complications of many pathologies related to vitamin D deficiency.