Résumé:
The effect of Aluminum chloride was investigated to describe the associated behavioral
and brain modifications. We don’t know enough about the biological chemistry of
chronic and sub- acute exposure to Aluminium to be able to predict its impact on human
health. Although the hypothesis of a link between Aluminium and Alzheimer’s disease
(AD) has been supported by several epidemiological studies. Extract of Hypericum
thymopsis (HTE), a well known medicinal plant, is used for the treatment of depression,
has been explored in the present study for its protective role against Aluminum
neurotoxicity. This data suggests that HTE may be a candidate for application in
neurodegenerative diseases such as Alzheimer’s disease. Results of this study
demonstrate that Aluminiumneurotoxicity play an important role in the development of
anxiety disorders, depression and memory deficit in mice, these alterations of behavioral
activities can be a cause of development of Alzheimer’s disease. HTE possesses
significant antioxidant activity and renders neuroprotection which was more pronounced
at the dose of 200mg/ kg against Al induced neurotoxicity. Chronic administration of
Hypericum thymopsis significantly improved retention in both tasks, attenuated
oxidative damage, Aluminum concentration in Aluminum treated mice (p 0,05).
Hypericum have neuropotective effects against Aluminum-induced cognitive
dysfunction and oxidative damage.
