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Pharmacological potential of Populus nigra extract as antioxidant, antiinflammatory, cardiovascular and hepatoprotective agen

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dc.contributor.author Debbache-Benaida, Nadjet
dc.contributor.author Atmani-Kilani, Dina
dc.contributor.author Schini-Keirth, Valérie Barbara
dc.contributor.author djebli, Noureddine
dc.contributor.author Atmani, djebbar
dc.date.accessioned 2018-07-12T09:44:36Z
dc.date.available 2018-07-12T09:44:36Z
dc.date.issued 2013
dc.identifier.issn 2221-1691
dc.identifier.uri http://hdl.handle.net/123456789/690
dc.description.abstract Objective: To evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract. Methods: Antioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver sections. Vasorelaxant effect was estimated in endothelium-intact and -rubbed rings of porcine coronary arteries precontracted with high concentration of U46619. Results: The results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl3-induced hepatic toxicity. Relaxant effects of the same extract on vascular preparation from porcine aorta precontracted with high concentration of U46619 were considerable at 10 -1 g/L, and comparable (P>0.05) between endothelium-intact (67.74%, IC50=0.04 mg/mL) and -rubbed (72.72%, IC50=0.075 mg/mL) aortic rings. Conclusions: The extract exerted significant anti-inflammatory, hepatoprotective and vasorelaxant activities, the latter being endothelium-independent believed to be mediated mainly by the of components present in the extract to exert antioxidant properties, probably related to an inhibition of Ca2+ influx. en_US
dc.language.iso en en_US
dc.publisher Asian Pac J Trop Biomed. en_US
dc.relation.ispartofseries 10.1016/S2221-1691(13)60141-0;3(9): 697–704.
dc.subject Populus nigra, Polyphenols, Anti-inflammatory activity, Hepatoprotection, Vasorelaxation en_US
dc.title Pharmacological potential of Populus nigra extract as antioxidant, antiinflammatory, cardiovascular and hepatoprotective agen en_US
dc.type Article en_US


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