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Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations LOUIZA BELKACEMI1,

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dc.contributor.author Belkacemi, Louiza
dc.contributor.author Selselet-Attou, Ghalem
dc.contributor.author BULUR, NURDAN
dc.contributor.author Louchami, Karim
dc.contributor.author Sener, Abdullah
dc.contributor.author Malaisse, Willy J.
dc.date.accessioned 2018-09-15T09:21:33Z
dc.date.available 2018-09-15T09:21:33Z
dc.date.issued 2011
dc.identifier.other DOI: 10.3892/ijmm.2010.556
dc.identifier.uri http://hdl.handle.net/123456789/750
dc.description.abstract The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the latter period, all animals were either given free access to food or fasting daily for 15 h, i.e. from 5.00 p.m. to 8.00 a.m. The body weight, liver wet weight, pancreas wet weight, plasma glucose and haemoglobin A1c concentration, plasma insulin concentration, insulinogenic index, insulin resistance HOMA, plasma cholesterol and triglyceride concentration, liver triglyceride and phospholipid content were all measured. Pancreatic islet (insulin, GLUT2) and liver (lipid droplets) histology were also examined. The main findings consisted in a lower body weight of fasting than non-fasting animals, a higher liver weight in non-diabetic and diabetic rats than in control non-fasting (but not so in fasting) animals, a decrease of pancreas weight in non-diabetic and diabetic as distinct from control animals, a fasting-induced decrease in plasma glucose, plasma insulin and insulin resistance HOMA, plasma cholesterol and triglyceride concentration and triglyceride liver content. en_US
dc.language.iso en en_US
dc.publisher Spandidos publication en_US
dc.relation.ispartofseries INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE;27: 95-102, 2011
dc.subject sand rats, intermittent fasting, insulin, liver triglyceride and phospholipid, pancreatic insulin and GLUT2 en_US
dc.title Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations LOUIZA BELKACEMI1, en_US
dc.type Article en_US


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