Résumé:
Lipase inhibitors have generated a great interest because they could help in the prevention or the therapy of
lipase‐related diseases. Therefore, the aim of this work was to evaluate the inhibitory effect of secondary metabolites
extracts such as phenolic compounds and saponins of three Algerian medicinal plants: Achillea santolina, Inonotus
hispidus and Zizyphus lotus, indeed their antiradicalaire activity using DPPH• (1, 1‐diphenyl‐2‐picryl‐hydrazyl). The
phenolic extracts have shown a strong antiradicalaire activity than the saponin extracts with EC50 values ranged from 6 to
11 μg/ml and from 51 to 82 μg/ml, respectively. The enzymatic inhibition produced by these plant extracts is described
here for the first time. The results have shown that the phenolic extracts are more potent than the saponin extracts with Ki
values ranged from 0.011 mg/ml to 0.027 mg/ml for phenolic extracts, and ranged from 0.071 mg/ml to 0.69 mg/ml for
saponin extracts. The nature, mechanism and possible physiological relevance of lipase inhibition by extract components
are discussed.
