Résumé:
The inflammation is a set of reactions generated by the body in response to a sustained assault.
It can be of foreign origin as an injury, infection, trauma, or come from the inside of the body
itself as in autoimmune diseases. Many plants are known for their use in traditional medicine
for the treatment of several diseases including diseases inflammatory component. Our research
has focused on the inedible date (kernel) part of the fruit of the date palm Phoenix named l.
variety Deglet-Nour of Algerian origin.
The focus of our study is to find a scientific basis for the use of date kernel in the therapeutic
field. It is based on two stolen; the first is the preparation of aqueous and Keto dates nuclei
extracts followed by qualitative phytochemical analyses which allowed to highlight several
secondary metabolites, this analysis has been supplemented by a determination quantitative
phenolic flavonoids and totals, the second concerns the assessment of the anti inflammatory
activity of the extracts in vivo. A histological study is conducted at the end of this experiment.
The anti-inflammatory activity was assessed by measuring the edema induced by carrageenan
a1% at the level of the sub-plantaire part of the leg of the NMRI mice. Results the percentage
of inhibition of edema of the leg of treated mice with the aqueous extract and the Keto extract
in 100, 200 and 300 mg/kg were disclosed a significant increase compared to the mice treated
with Diclofenac® 50 mg/kg After the injection of the carrageenan.
The cutaneous tissue of mice paw histopathological results confirms the anti-inflammatory
effect of two Keto from the inedible part of dates and aqueous extracts. This experimentation
allows us to affirm the anti-inflammatory activity of the two extracts of kernel (DegletNour)
date of Algerian origin, according to the conditions of our study.
