Abstract:
Although the prevalence of food allergies is rising, the standard of care medical for these
types of allergies is suboptimal. Probiotics have been reported to regulate the allergic immune
response, but the underlying mechanisms are not fully understood. In this study, we detail in a
new research which aims to evaluate the effect of a mixture of probiotics on food allergy in an
ovalbumin (OVA)-induced murine model according to the work of Ma et al. (2019). The results
found in this recent study showed that the treatment with the probiotics attenuated OVA-induced
allergic symptoms in mice. Flow cytometry analysis showed that oral administration of probiotics
induced the dendritic cells, which promoted differentiation of regulatory T cells. 16S rRNA
analysis revealed that the probiotics modulated the composition of microbiota, especially by
increasing the proportion of the Deferribacteres and Verrucomicrobia phyla and the
Mucispirillum and Clostridium XlVa genera, which in turn regulated the immune system. These
findings provide a clear molecular insight into the application of a mixture of probiotics to
alleviate food allergies and even to protect gut immune homeostasis.
