Contribution à l’étude du statut de la vitamine D et de quelques paramètres biochimiques et anthropométriques chez une population de Mostaganem (Ouest de l’Algérie)

Abstract

Vitamin D is now experiencing a resurgence of interest, not only because of its interesting bone effects in the prevention of osteoporotic fractures as its protean extra osseous effects (reduction in the risk of cancer, inflammatory diseases and even mortality, etc.) observed in large observational studies. Measuring 25-hydroxyvitamin D levels is now a very reliable method of assessing individual stores The objective of this work is to determine the prevalence of hypovitaminosis D in the population of the Mostaganem region and its risk factors, to study the correlations between the 25(OH) D level and demographic, clinical and biological parameters. The 25 (OH) D levels were distinguished into 3 groups: normal dosage (≥ 30 ng / ml), insufficiency (10 - 30 ng / ml) and deficiency (<10 ng / ml). The explanatory variables studied were: age, body mass index, origin, sex, phototype, type of clothing. This is a prospective epidemiological study including 120 volunteers of both sexes (94 women and 26 men) aged between 12 and 86 years. We tested for 25(OH) D, PTH and calcium. These are 120 patients with an average age of 51.27 years, the prevalence of hypovitaminosis D (25-OH-D <29ug / l) is 86% in the general population 89% in women and 74% in men. The analyzes objectified a correlation between the dosage of 25 (OH) and the sex and the phototype such that a positive and significant correlation was found between the 25OHD and the PTH (r = 0.27; p = 0.001). There was, however, no significant correlation between 25(OH) D level and serum calcium concentration. The prevalence of 25 (OH) D deficiencies in the study population (86%) of the Mostaganem region is a matter of concern for their future health. Our results underline the importance of systematic supplementation in this particularly at-risk population.