Évaluation de test de toxicité aigüe chez les rats par l'effet de plante médicinale de la famille Lamiaceae

Abstract

A study was conducted to assess the acute toxicity of Phlomiscrinita, a medicinal plant of the Lamiaceae family, in Wistar rats.This memory presents an experimental study that evaluates the effects of a gavage on an animal model, and is concentrated on more biological parameters and morphologies. After the product test administration through oral (gavage) period by an aqueous extract , a quarter-hour observation period is in place to monitor all clinical signs related to mobility, respiration, neurological reactions or physical examination. This Mediterranean medicinal plant from the Lamiaceae family is traditionally used to treat inflammation, respiratory conditions, and wounds. It has antioxidant and antibacterial properties.Medicine based on the use of plants to prevent or treat various diseases. It is considered an alternative or complement to conventional medicine.In completion, biochemical and hematological analyzes have been performed on previous. These analyzes on the valuer note the hepatic parameters (ALT, AST, bilirubin), Renaux (creatinine, uree), as well as the complete sanguine formula includes the globules of rouges, blancs and plaquettes.In the experimental issue, a post-mortem macroscopic analysis has an effect on the principal organs (liver, brain, lungs) to identify all visible lesions or anatomical changes.Infinity, this histological method is connected to part of the colored tissue in hematoxyline-eosine (H&E), allowing you to apply the cellular alteration or tissue inserted into the product.The histological and biochemical analyses performed were within normal limits, indicating the absence of significant pathological alterations. The observed tissues exhibited normal cellular structure, with no signs of inflammation, necrosis, or hypertrophy. From a biochemical perspective, the measured parameters, such as liver enzymes, renal markers, and glucose and protein levels, were within physiological ranges. These results suggest that the overall condition of the organs studied is healthy and that metabolic functions are maintained normally.The sense of these resultsfrom a global public health system, servant of the base for a preliminary evaluation of the toxic substance or the innocuit of the composition test