Résumé:
The objective of this study is to demonstrate the protective effect of Tigzirt's propolis
(EAP) ethyl acetate extract on certain antioxidant status parameters and markers of
hepatocellular nephrotic And epirubicin induced cardiotoxicity (EPI). A total of 25 male
Wistar rats (mean weight between 100 and 150 g) were divided into 5 batches receiving EAP
or quercetin (as standard flavonoids) before and after induction of toxicity by Epirubicin (9
mg / kg) by intravenous injection (iv). At the end of the experiment, blood samples were
taken by cardiac puncture. The results show that epirubicin induced metabolic alteration with
increased serum levels of biochemical parameters and enzymatic activity (urea, creatinine,
ASAT, ALAT, PAL, γGT, LDH, CKmb, Troponin T). While administration of propolis
restored cardiac, renal and hepatic function. The effect of polyphenols of ethyl acetate extract
of Tigzirt propolis on oxidative stress appeared in rats treated with 200 mg / kg / d dose where
there was a decrease in MDA malondialdehyde and a Increase in superoxide dismutase SOD
and glutathione peroxidase GSH-Px. Our results suggest that propolis may reduce the toxicity
induced by epirubicin.
