Exploration de l’activité antioxydante et anti-inflammatoire d’Elettaria cardamomum

Abstract

In this present study, the antioxidant and anti-inflammatory activities were aimed at evaluating and studying the protective effect of Elettaria cardamomum. The determination of phenolic compounds (polyphenols and flavonoids) was estimated at a very efficient level of 343.90 ± 32.26 mg EAG / g extract and 305.65 ± 64.27 mg EQ / g extract respectively. In addition, for the anti-radical activity was evaluated more than 90% at a concentration of the order of 100 μg / mL of EEC extract compared to the concentration of 10 μg / ml of extract of EEC of which; the radical inhibition was approximately 50%. In addition, the ethanolic extract of E. Cardamomum (EEC) has an IC50 of 11.2 μg / mL. Moreover, the results of the inflammation caused by the intraperitoneal injection of carrageenin in Wistar rats revealed that, through the administration of 200 mg / kg / EEC, a proportion of 8 g / l of total protein and 4.5g / dL of albumin were estimated in rats. On the other hand, 2.5 g / l and 1.5 g / dL of total protein and albumin respectively in the control group rats. In addition, a significant content of fibrinogen and glycemia in the control rats; exposed to 200 μl of carrageenan. In addition, the histopathological study reveals that the liver of rats treated with 200 mg / kg / EEC after being injected with 200 μl of carrageenan has a normal histological structure of the hepatic parenchyma, hepatocytes and central veins lobular except for slight congestion. It can be concluded that the ethanolic EEC extract containing phenolic compounds has antioxidant and anti-inflammatory properties.