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Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats

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dc.contributor.author Belkacemi, Louiza
dc.contributor.author Selselet-Attou, Ghalem
dc.contributor.author Hupkens, Emeline
dc.contributor.author Nguidjoe, Evrard
dc.contributor.author Louchami, Karim
dc.contributor.author Sener, Abdullah
dc.contributor.author Malaisse, Willy J.
dc.date.accessioned 2018-09-15T08:47:33Z
dc.date.available 2018-09-15T08:47:33Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/123456789/748
dc.description.abstract This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. en_US
dc.language.iso en en_US
dc.publisher International Journal of Endocrinology en_US
dc.relation.ispartofseries Volume 2012, Article ID 962012;
dc.subject Intermittent Fasting, treptozotocin- diabetci rats, apoptosis, β-Cell Mass en_US
dc.title Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats en_US
dc.type Article en_US

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