La neurotoxicité de l’aluminium, intéraction maladie d’Alzheimer-contribution à un traitement par le curcumin (étude expérimentale chez la souris)

Abstract

The versatility of Aluminium chemistry will ensure its burgeoning use in the future in all manner of applications. This very same chemistry will also ensure its increased biological availability in all biota including Man. We do not know enough about the biological chemistry of a chronic and sub-acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis of a link between Aluminium and Alzheimer's disease (AD) has been supported by several epidemiological studies, there is much controversy regarding these findings and their interpretation. There is no doubt that the drugs discovered for neurodegenerative disease are far from ideal, there are no more than acetylcholinesterase inhibitors, in fact alternative medicine could be moderate and protect nerves from neurotoxicity and AD. Curcumin is one of strong medicinal species that prove antioxidative stress effect against reactions cascade of neurofibrillary tangles. Our aims is to clarify the role of Curcumin with a fixative of absorption as a protective and therapeutic agent against neurodegenerative disorders and Alzheimer's disease induced by AlCl3 on the pyramidal cells in cerebral cortex and hippocampus of albino mice, by means of Two experiences realized with a different exposition of albino mice; sub acute and chronic exposure with a different manner (Oral and IP) on Curcumin and AlCl3