High in vitro antiurolithiatic effect of Pituranthos scoparius roots extracts

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dc.contributor.authorYousfi, M
dc.contributor.authorBenalia, H
dc.contributor.authorDjeridane, A
dc.contributor.authorBensafieddine, F
dc.date.accessioned2019-06-18T10:14:37Z
dc.date.available2019-06-18T10:14:37Z
dc.date.issued2016-04-30
dc.description.abstractTherichnessofthesteppezonebythemedicinalplantsandtheirdiversitytraditionalusesintheregionofLaghouat,allowedustostudytheinhibitoryeffectofHerniariafontanesiiJ.Gay,PituranthosscopariusandCynodondactylon(L)extractsontheformationofcalciumoxalatekidneystones.Firstly,wehavecarriedoutphytochemicalscreeningandquantitativeanalysisofphenoliccompoundsofvariousextractsfromthethreeplants.TheobtainedresultsprovedthatourextractsarerichincatechictanninsandC-,O-heterosides,withatotalphenoliccontentrangedfrom0.867to38.835mgofgallicacidequivalentper1gofdrymatter. Theinvitroantiurolithiaticactivityofdifferentplantsextractshasbeencarriedoutbytwodifferentmodels.Intheturbidimetricassay,wehavedeterminedspectrophotometricallytheeffectoftheextracts(1g/L)ontheoxalocalciccrystallization,inducedbyadditionofoxalateinurinesfromhealthysubject.Whereas,thegravimetricassayisbasedtomeasurethevariationofcalciumurateanduricacidrenalcalculiweight,afterputtingthemincontactwith5mloftheextracts(5g/L)during15days.Inthetwoassays,theantiurolithiaticactivitywascomparedwiththatoftwoantiurolithogenesisinhibitorystandards:sodiumcitrateandSuccinimidepharbiol.Theachievedresultsmeasuredbythetwotests,showclearlythatthehydromethanolicextractsofPituranthosscopariusrootshaveprovidedveryimportantantiurolithiasicpower(>40%ofinhibition)comparedtothestandardinhibitors.However,thisresultisagreatstepforwardtowardsthesearchforaneffectivetreatmentfortheurinarycalculiformation.But,thisworkwillhavetobeconfirmedbyinvivoexperimentsinordertovalidatetheseinvitroobservationsonthecontributionsofthesethreeplantsinthetreatmentoftheoxalocalcicrenalcalculi.en_US
dc.identifier.urihttp://e-biblio.univ-mosta.dz/handle/123456789/10920
dc.publisherPhOLen_US
dc.subjectMedicinalplantsen_US
dc.subjectPituranthosscopariusrootsen_US
dc.subjectphytochemicalscreening,kidneystonesen_US
dc.subjectCalciumoxalateen_US
dc.subjectantiurolithiasicen_US
dc.titleHigh in vitro antiurolithiatic effect of Pituranthos scoparius roots extractsen_US
dc.typeArticleen_US

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