Etude des déterminants génétiques et environnementaux du diabète de type 2 et Hba1c

Abstract

Type 2 diabetes (T2DM) is now a major public health problem worldwide. A better understanding of the etiology of the disease, in particular by studying genetic susceptibility factors as well as gene-environment interactions, is necessary to develop effective preventive and therapeutic strategies. In this thesis, we first characterized the environmental risk factors for the occurrence of T2DM in a representative sample of the Algerian population. Moreover, Glycated hemoglobin (HbA1c) is the key parameter for the investigation of glycemic control in diabetic patients. Its dosage is carried out by well-controlled techniques, the advantages and limits of which must be known when interpreting the results in clinical practice. HbA1c tests are standardized against an international reference method, which makes it possible to obtain comparable results from one method and from one laboratory to another. Our study of the HbA1c assay method, an immunoturbidimetric method (on a chromatographic method (HPLC Bio-rad D-10). The understanding of the relationship between the usual values of glycated hemoglobin (HbA1c), glycaemia, eating habits as well as the rhythm of life in forty type 2 diabetic subjects, allowed the development of a set of observations, based on certain parameters such as: age, sex, diet, stress etc.,.