Contribution à l’étude d’une maladie héréditaire liée à l’X; l’hémophilie À propos de 24 cas au niveau de l’établissement hospitalo-universitaire (EHU) d’Oran

Abstract

Hemophilia is an inherited bleeding disease with an X-linked method of transmission. This is a relatively rare condition characterized by a deficiency of factor VIII (hemophilia A) or factor IX (hemophilia B) of the coagulation. The objective of this work, carried out at the level of the hemobiology laboratory of the university hospital establishment (UHE) of Oran (from February 16 to March 16, 2020) was to deepen our knowledge about hemophilia, and learn the diagnostic techniques used in routing, which are: Prothrombin time (PT); Activated partial thromboplastin time (APTT) or Kaolin partial thromboplastin time (KPTT) and F factor We have collected 24 cases of hemophilia type A this period, with hemophilia B being very rare. The average patient age was 12,1 years, the majority of patients were children from 1 to 16 years old, constituting a rate of 69%, while patients aged between 24 years and 43 years old represented only 26%. Determining the level of factor F enabled us to classify the type of hemophilia into 60% severe, 30% minor and 10% moderate hemophilia. PT values are disturbed (below standards) in 22 of 24 patients (91,7%) and APTT values are disturbed (above standards) in all patients. Treatment of hemophilia is complex and costly, and the best way to fight it is preventive health education for patients and parents.