Étude Clinico-Biologique de la Maladie Coeliaque chez le nourrisson l'Enfant et l'Adolescent dans l’ouest algerien

Abstract

In a few years, celiac disease has become a public health problem. This autoimmune disease is induced by the ingestion of gluten contained in wheat proteins, rye and barley in genetically predisposed individuals. Recent studies have provided insight into the mechanism involved in this breach of oral tolerance. Complications are rare, but potentially harmful. Although the gluten-free diet allows full recovery, its observance is not universal so that other therapeutic strategies are being evaluated. It appears to be difficult to achieve in most patients for various reasons. The main immediate consequence is malnutrition. Among those aged under 18 years, 16% of boys and 39% of girls presents with thinness. In adults, 52% of patients have a normal BMI, 18% shows malnutritional status grade I, 7% grade II malnutrition and 4% grade III malnutrition. BMI in adult patients is influenced by the level of education and socioprofessional level. . This thesis brings together the latest pathophysiological data and new the rapeutic hopes for celiac disease.