Etude de quelques complications biochimiques liées au développement de la maladie coeliaque

Abstract

Celiac disease is an inflammatory autoimmune enteropathy, occurring in genetically predisposed individuals. It is triggered by the consumption of gluten which induces chronic intestinal inflammation which causes malabsorption. Objective. Determination of some biochemical parameters (CRP, TGO, TGP, TP) in people with celiac disease. Methods. A total of 30 cases with celiac disease, men and women (F / M: 18/16), were detected in different private medical laboratories by sampling during a period from August 2019 to March 2021. The age varied between 10 months and 46 years. Patients with a negative tTG-IgA (anti-tissue transglutaminase IgA) test were excluded, while patients with a positive test (value> 15 iu / ml detected by ELISA) were included. The biochemical profile comprising the reactive protein C, glutamate-oxaloacetate-transaminase (TGO), glutamate-pyruvate-transaminase (TGP), prothrombin level was estimated at the medical analysis laboratory "Dr. GHEZALI" by taking a blood sample. centrifugal. Results. All patients were divided into four groups according to age group. The results obtained are identical for the two groups whose age <10 years and 20-30 years; (mean, 21 ± 13.37) 33.33%. The biochemical assessment showed that the content of C reactive protein was significantly high (p <0.001) in 20% of the cases studied. Likewise, glutamate-oxaloacetate-transaminase (TGO) and glutamate-pyruvate-transaminase (TGP) showed a very significant increase (p <0.01) in 23.33% and 10% respectively. However, the prothrombin level was significantly (p <0.05) elevated in only 3.33%. Conclusion. This study shows that celiac disease could induce an alteration of some biochemical parameters (CRP, TGO, TGP, TP).