Prévalence de la Stéatose Hépatique Non Alcoolique (NAFLD) et de maladies sous-jacentes dans la population de Mostaganem

Abstract

The work presented in this master’s thesis is a transversal study carried out via a questionnaire. Our epidemiological research shows the relationship between the non-alcoholic steatosis NAFLD (not Alcoholic Fatty liver Disease) and the various associated diseases. The latter are high blood pressure (hypertension), type 2 diabetes, hepatitis B and hepatitis C. NAFLD is the most common chronic disease NAFLD is the most common chronic liver disease.It encompasses a broad spectrum of histological entities and is considered the liver manifestation of metabolic syndrome (MS). NAFLD and its more severe form, non-alcoholic steatohepatitis (NASH) whose complications can lead to cirrhosis and hepatocellular carcinoma (CHC). Obesity, dyslipidemia, type 2 diabetes and insulin resistance (IR) are important risk factors for NAFLD. Estimating these factors therefore makes it possible to predict the risks of NAFLD. The study population is a cohort of patients treated at the local health centre in the wilaya of Mostaganem. The main objective is the case study of NAFLD and on a number of 58 patients 14 suffer from this disease. Or 24% of the population identified are affected by this disease.We were able to establish the diseases identified are NAFLD Hepatitis B (HBV), Hepatitis C (HCV), Budd Chiari, Autoimmune hepatitis and Cirrhosis. But there is a predominance of patients with HBV and HCV with a percentage of 34% and 28% respectively. For NAFLD associated with HBV, Budd-Chari disease and autoimmune hepatitis, they represent respectively 7%, 5%, 4% and 2% of patients. This study highlights the clear interaction between the risk of NAFLD and associated diseases and key risk factors.