Evaluation de quelques paramètres biochimiques chez la femme enceinte atteinte d’une insuffisance rénale chronique

Abstract

Kidneys are vital organs for human beings due to their purifying role. Every kidney contains around a million nephrons. Indeed, a simple pathology of this unit will result in a nephropathy which over time and complications may lead to chronic renal failure. In addition, even if woman’s fertility diminshes with the progression of renal insufficiency, we are faced with a pregnancy associated to this pathology. This pregnancy is considered as a pregnancy at risk considering the complications that it causes leading to the fetal death. This research work aims at identifying the risk factors in the pregnant woman with a renal failure and, eventually, avoiding the complications by comparing normal biological parameters with pathologies. The parameters studied are: urea, creatinine, uric acid, hemoglobin, calcium, sodium and potassium. The results obtained show that a pregnancy during renal failure increases irreversible alteration of the glomerular filtration system, of the tubular and endocrine function of the kidney since an increase of the creatinine rate, urea, Na++ and K+ is observed; as well as a decrease in the uric acid rate and Ca++. To conclude, pregnancy during renal failure may not be advisable since it represents a high risk for the mother as well as for the baby and it needs medical supervision of the biochemical parameters for the follow-up care of the renal function (the extent to which the kidney is affected) and to avoid any complications.