Effet anti-tumoral de l’extrait des graines de Lepidium sativum L. sur des souris soumises à un régime riche en nitrite de sodium

Abstract

The main objective of this research is to evaluate the anticarcinogenic and therapeutic activities (In Vivo) of ethanolic extract of Lepidium sativum L. seeds, which has multiple medicinal properties. Our experimentation was carried out on 24 Swiss albino mice, divided into 4 groups, which were given daily oral administration of a carcinogen (sodium nitrite Na NO2) for 6 months. Of which two experimental groups were treated with doses of 50mg/kg, 200 mg/kg of L.sativum seeds extract respectively for the entire period of exposure to the carcinogen, and one group was treated with 50mg/kg during the sixth month only, as well as positive controls group. The results obtained show a significant variation in the relative weights of the mice and organs of the groups exposed to the carcinogen; notable changes in the biochemical and haematological parameters studied. Histological examination revealed that the carcinogen causes tumour necrosis and liver damage in the positive control group. On the other hand, the treatment with the ethanolic extract of Lepidium sativum seeds proved its effective preventive and curative effects against this tumour.