CANCER MAMMAIRE ET LA MUTATION BRCA1

Abstract

In Algeria, breast cancer is the most frequent malignant tumor and the leading cause of cancer death in women. It is a complex and heterogeneous disease. This heterogeneity is found at the histological, phenotypic and molecular level. It remains an ill-known disease and the current clinical and histological classifications do not allow to predict the prognostic and predictive parameters. The predisposition to breast cancer is inherited as a dominant trait.The presence of mutations with founding effect in the founding populations facilitates the discovery of highly penetrating alleles in high-risk individuals within families with a hereditary susceptibility to breast cancer. Our goal is to do a theoretical study on the mammary gland, demonstrated the importance of breast cancer and its relationship with the mutation BRCA1