Exploration des Activités Biologiques de l’Extrait des feuilles de Laurus nobilis L. In vitro et In vivo

Abstract

The present study aimed to highlight the biological activities of Laurusnobilis extract. The analysis of this extract revealed the presence of some chemical groups (total polyphenols and flavonoids) capable of expressing the desired activities and their contents were determined by spectrophotometric methods. The extract was been also screened for its possible antimicrobial activity in vitro, against eight pathogenic bacteria strains and two yeast species, using the diffusion method from a solid disc. The extract reacted positively on the microbial strains tested. Then, theMICs were determined. The investigation of the anti-inflammatory activity in vitro has shown that the extract has a strong ability to inhibit 94.64%of protein denaturation. As it proved significantly itsin vivo efficacy in reducing 98.68% of carrageenin-induced plantar edema in mice. In addition, the extract significantly demonstrated its analgesic activity by reducing acetic acid-induced contortions by 40% in mice. Similarly, administration of the extract exerted a85.9 % inhibition of acetic acid-induced vascular permeability in mice.