Activité anti-inflammatoire de certaines bactéries probiotiques isolées du poisson

Abstract

Probiotic bacteria have the ability to alter the immune response by providing treatment for inflammatory diseases. In the present study we have studied several articles carried out in order to explore the anti-inflammatory potential of probiotic bacteria in order to study the maximum of parameters; the first study carried out in vitro focused on the immune response at the genetic level of Caco-2 cells having undergone inflammation induced by lipopolysaccharide and treated with probiotics of the genus Lactobacillus plantarum subsp. Subsequently, the gene expression of the pro-and anti-inflammatory genes was studied by PCR. Regarding the second article, functional properties as a long-term sustainable supplement for inflammation As well as the effect of non-steroidal anti-inflammatory drugs (NSAIDs) were explored on strains of lactic acid bacteria whose anti-inflammatory potential was already studied as well as 'a multi-strain probiotic formulation (L. rhamnosus, b. Lactis and b. Longum). The results of this research demonstrated the anti-inflammatory power of probiotic bacteria at the genetic level, the strains studied had downregulated the gene expression of pro-inflammatory cytokines and up-regulated anti-inflammatory cytokines. As well as on the reduction of inflammatory edema or Lactobacillus spp showed an anti-inflammatory capacity by a significant reduction in the thickness of the legs (P <0.05) showing a percentage of inhibition of 15.67%, 14 , 72% and 14.84% respectively 24 hours after induction of carrageenan as regards the formulation studied, a significant increase in the production of anti-inflammatory cytokine IL-10a could decrease the secretion of the main pro-inflammatory cytokines IL-1β and IL-6 by 70% and 80% respectively. Finally, we have demonstrated anti-inflammatory properties on various models of inflammation in vitro / in vivo, but all of these results suggest further studies to promote the health benefits of probiotic bacteria.