Exploration du lien biochimique entre la réponse inflammatoire CRP et l’hypovitaminose D

Abstract

Vitamin D is a fat-soluble vitamin essential for maintaining calcium-phosphorus homeostasis and bone health. It also plays an important role in the modulation of immune and inflammatory responses. C-reactive protein (CRP), on the other hand, is one of the main biological markers of inflammation. Several studies have suggested a relationship between vitamin D deficiency and increased inflammatory markers; however, the findings remain controversial. The aim of this study was to evaluate the association between serum vitamin D concentrations and CRP levels in patients who underwent both biological tests simultaneously at the Dr. Mehdi ETTALHI Medical Analysis Laboratory in Mostaganem. This study included 219 patients, comprising 49 men and 170 women. Vitamin D levels were measured using the automated VIDAS® BioMérieux method based on the ELFA technique, whereas CRP was assessed using an automated method on the Zybio EXC200 analyzer as well as a manual immunoturbidimetric agglutination method. Statistical analysis was performed using the Chi-square test. The results revealed a high prevalence of vitamin D deficiency (73.97%), observed mainly among women. Regarding CRP, 57.99% of patients presented normal values. Statistical analysis showed no significant association between vitamin D concentrations and CRP levels. In conclusion, this study highlights the high frequency of vitamin D deficiency in the studied population, without a significant relationship with CRP variations. Further studies involving larger sample sizes and additional inflammatory markers are needed to better understand the interactions between vitamin D status and inflammation.