ETUDE ANATOMOPATHOLOGIQUE ET IMMUNOHISTOCHIMIQUE DU CANCER COLORECTAL

Abstract

Colorectal cancer, represents a major public health problem in the rich countries of the planet, because of its frequency and especially because of its seriousness. In Algeria, the incidence of this cancer remains low compared to developed countries. However, this incidence is constantly growing. The results of our study revealed a predominance of men with a sex ratio of 1.4 for high frequency of malignant involvement of the left colon (76%) compared to the right colon (24%). The majority of colonic tumors are lieberkühnian adenocarcinomas with a frequency of 93% against 7% of mucous colloid form. The study of the distribution of the sub types of lieberkuhnian adenocarcinomas showed that the form of well differentiated adenocarcinoma appears dominant with a frequency of 59.28% followed by moderately differentiated and poorly differentiated adenocarcinoma with respective frequencies of 31.1% and 3.68%. . The lieberkühnian type of adenocarcinoma appears to be dominant in both sexes compared to the type of colloid mucous adenocarcinoma. For lieberkuhnian adenocarcinoma the frequencies are in the order of 54.6% in men and 39.26% in women. The phenotype of CK7 and CK20 made it possible to distinguish intrahepatic cytokeratins from metastases of colorectal adenocarcinoma. To this end, it would be interesting to carry out a nutritional survey in order to determine the important role of food in the etiology of this type of cancer, to set up a mass screening program in individuals 50- 74 years old and to perform a Hemoccult® test every two years, across our country.