Etude des paramètres clinicobiologiques chez les patients atteints par la COVID-19.

Abstract

Corona virus disease 2019 is a highly transmissible disease caused by severe acute respiratory syndrome corona virus 2 which poses a major threat to global public health, although COVID-19 mainly affects the respiratory system causing severe pneumonia and the acute respiratory distress syndrome in severe cases leading to critical and lifethreatening clinical complications. Recently published studies have found cytokine storm and clotting disorders to be the main serious complicating factors of COVID-19. In our study, 150 patients with SARS-CoV-2 were admitted to the service of the Cheguevara hospital (resuscitation and infectious) were divided into two cohorts: 100 patients died against 50 cured, we took into account age, gender and the presence of comorbidities. The aim of our work is to study the impact of the fluctuation of clinicobiological parameters in patients with COVID-19. The results revealed that the presence of comorbidities and advanced age associated with high levels of biological parameters are significantly associated with death (P˂0.05) and that men are significantly more affected by this pandemic compared to women (P ˂0.05). The entry of the virus into the host cell mainly induces an excessive inflammatory response in the lungs leading to a cytokine storm responsible for tissue damage and high levels of biological parameters.