L’effet Neuroprotéctive d’un Mélange de deux Plantes Médicinales : Mushroom et Curcumine (Bioglucumin) sur la Maladie d’Alzheimer. Etude in vivo chez la souris « NMRI »

Abstract

Alzheimer's Disease is a progressive neurodegenerative dementia with multiple disorders. It is characterized by the presence in the brain of amyloid plaques and neurofibrillary degeneration which cause neuronal death, vascular dysfunction and inflammatory processes. This study is part of the search for new natural neuroprotectors. The main objective of this work is the study of neuroprotection against Alzheimer's disease by a natural extract seen its richness by antioxidants. The extract chosen in our experimentation is Bioglucumin; Mixture of two extracts of medicinal plants (Mushroum and curcumin) Alzheimer's disease was induced for 45 days followed by Bioglucumin extract phytotherapy for 45 days in young mice (NMRI strain). The results obtained show that the preventive treatment by Bioglucumin managed to solve some problems and behavioral changes (locomotor activity, anxiety test, cross test, forced swimming test), memory tests (non-spatial memory test Preferably conditioned, distinguished in position, thus the storage capacity is improved during the Morris test) and even some biochemical parameters with tissue improvement in the histological study.