Résumé:
Probiotic bacteria have the ability to alter the immune response by providing treatment
for inflammatory diseases. In the present study we have studied several articles carried out
in order to explore the anti-inflammatory potential of probiotic bacteria in order to study
the maximum of parameters; the first study carried out in vitro focused on the immune
response at the genetic level of Caco-2 cells having undergone inflammation induced by
lipopolysaccharide and treated with probiotics of the genus Lactobacillus plantarum subsp.
Subsequently, the gene expression of the pro-and anti-inflammatory genes was studied by
PCR.
Regarding the second article, functional properties as a long-term sustainable
supplement for inflammation As well as the effect of non-steroidal anti-inflammatory
drugs (NSAIDs) were explored on strains of lactic acid bacteria whose anti-inflammatory
potential was already studied as well as 'a multi-strain probiotic formulation (L.
rhamnosus, b. Lactis and b. Longum).
The results of this research demonstrated the anti-inflammatory power of probiotic
bacteria at the genetic level, the strains studied had downregulated the gene expression of
pro-inflammatory cytokines and up-regulated anti-inflammatory cytokines. As well as on
the reduction of inflammatory edema or Lactobacillus spp showed an anti-inflammatory
capacity by a significant reduction in the thickness of the legs (P <0.05) showing a
percentage of inhibition of 15.67%, 14 , 72% and 14.84% respectively 24 hours after
induction of carrageenan as regards the formulation studied, a significant increase in the
production of anti-inflammatory cytokine IL-10a could decrease the secretion of the main
pro-inflammatory cytokines IL-1β and IL-6 by 70% and 80% respectively.
Finally, we have demonstrated anti-inflammatory properties on various models of
inflammation in vitro / in vivo, but all of these results suggest further studies to promote
the health benefits of probiotic bacteria.
