Résumé:
Hepatocellular carcinoma is a condition that occurs almost universally in people with
underlying liver disease and is therefore amenable to surveillance.
The goal of this research was to determine the different epidemiological, clinical and
serological aspects of cirrhosis and cirrhotic liver CHC.
The study of our 16 patients was carried out in the University Hospital to Mostaganem
in agreement with the Mazagran Oncology Center, taking into account the analysis of
biochemical assays and tumor markers in the laboratory and the various clinical abnormalities
of the patients through the consultations of specialist doctors and the medical records of each
patient, thus studying the morphological aspects of the liver by liver biopsy puncture.
The results obtained first revealed a significant prevalence which confirms the severity
of hepatic decompensation linked to the presence of hepatic insufficiency including jaundice
(50%), hepatic encephalopathy (18.25%) and portal hypertension where the common
pathological aspects were ascites (81.25%) and esophageal varices (56.25%). Second, the latter
allowed the assessment of liver damage by measuring the degree of severity of cirrhosis by the
Child Pugh stage C score (63%) and stage B score (37%), and by performing a PBH as a
histological study to determine the size of the nodules and liver masses. Finally, the results
revealed a moderate increase in transaminases, gamma GT, alkaline phosphatase, urea, total
bilirubin, CRP, platelets and a decrease in TP, albumin and creatinine. Finally, an increase in
all tumor markers in cancer patients was observed.
It is concluded that portal hypertension and the appearance of ascites fluid are indicative
of cirrhosis that can develop in CHC, manifested by the appearance of multiple peritoneal
nodules and liver masses.
