Variations des paramètres biologiques chez les femmes diabétiques de type 2 en fonction des stades physiologiques de la ménopause

Abstract

The aim of this study was to follow the evolution of certain biological parameters in type 2 diabetic women according to the physiological stages of menopause. In the first phase, 163 patients aged over 45 were recruited. Using a questionnaire, patients were classified according to age, BMI, personal history of arterial hypertension (AH), renal failure (RF), dyslipidemia and family history of diabetes. In the second phase of the study, a biological blood test was carried out on 78 patients divided into 26 subjects for each stage of menopause (pre-menopause, -menopause and post-menopause), including: blood glucose, glycated hemoglobin, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, microalbuminuria and hormone levels. The mean BMIs obtained in all diabetics involved in the study during the three stages of menopause (pre-menopause, menopause and post-menopause) were similar (P > 0.05) and ranged from 27.31 to 28.13Kg/m2. With regard to the biochemical profile, it was found that the majority of patients, depending on the stage of menopause and therefore age, had comparable and above-normal blood glucose levels, with blood glucose values ranging from 1.62 to 1.84 g/l and HbA1c levels from 8.23 to 8.63. The lipid profile showed relatively higher plasma concentrations than the accepted norm for triglyceridemia values, irrespective of age or stage of menopause. The other lipid analyses, including HDL and LDL, which varied inversely, showed no great change with age. However, the lowest cholesterol values (P<0.01) were found in the post-menopausal age group, whereas in both premenopausal and post-menopausal women, the results were significantly (P<0.01) higher (2.17 vs. 2.13 g/l). Microalbuminuria, uremia and createnemia showed non-significant age-related variations, confirming the good preservation of renal function in the various study populations. Finally, the results of the hormonal assessment obtained showed that there are indeed significant differences in the levels of FSH, LH and estradiol measured during the three stages of menopause. These values appear to be higher during pre-menopause and menopause.