Résumé:
The objective of this study was to evaluate the anti-obesity effect of ethanol extract of propolis in male Wistar
rats rendered obese by a hypergras diet. 30 rats weighing 80-110 g were divided into five groups: untreated
group 1 (control) receiving a standard diet, group 2 receiving a cafeteria diet and without treatment, the 3rd
group treated with the ethanolic extract of propolis (100 mg/ kg), the 4th group also treated with propolis extract
(200 mg / kg) and the cafeteria diet, and the fifth group receiving a cafeteria diet and treated with quercitine (50
mg/ kg).The results obtained in this study clearly show that the cafeteria diet induces an obesity characterized by
hyperglycemia in animals. However, the weight of obese rats treated with propolis (200mg/kg) increased more
rapidly compared to obese rats treated with propolis (100mg / kg) and a remarkable weight improvement for
obese rats treated with 50 mg / kg of Quercitine, glycated hemoglobin level (HbA1C) is also reduced by the
effect of propolis and quercetin. The effect of propolis on the concentration of HbA1C is dose-dependent.
Furthermore, creatinine and urea concentrations also decrease in obese rats under the effect of propolis;
Suggesting an improvement in renal function. The lipid profile (triglyceride-cholesterol) of the obese rats was
decreased by propolis and an increase in plasma triglyceride and cholesterol levels was observed in rats treated
with Quercetin compared with untreated obese rats. Propolis administered no effect on TGP compared with the
group of quercitin-treated rats that induced an increase over the control group and untreated obese rats. In
contrast to the plasma TGP concentration of Treated rats depends on the concentration of propolis and the
presence of quercetin in comparison with untreated diabetic rats.
