Résumé:
In Algeria, breast cancer is the most frequent malignant tumor and the
leading cause of cancer death in women. It is a complex and
heterogeneous disease.
This heterogeneity is found at the histological, phenotypic and
molecular level. It remains an ill-known disease and the current clinical
and histological classifications do not allow to predict the prognostic
and predictive parameters.
The predisposition to breast cancer is inherited as a dominant trait.The
presence of mutations with founding effect in the founding populations
facilitates the discovery of highly penetrating alleles in high-risk
individuals within families with a hereditary susceptibility to breast
cancer.
Our goal is to do a theoretical study on the mammary gland,
demonstrated the importance of breast cancer and its relationship with
the mutation BRCA1
